Vitamin D and Curcumin Improve Psoriasis

Supplementation with vitamin D and curcumin may provide safe and beneficial adjunctive treatment for psoriasis, according to an article published in Clinical Nutrition.* The meta-analysis included 21 randomized controlled trials involving 1,463 individuals with plaque psoriasis, a chronic autoimmune disease that causes thick, red, scaly patches on the skin. Compared to those who received conventional therapy alone, supplementation with vitamin D led to a statistically significant reduction in Psoriasis Area and Severity Index (PASI) scores, a system used to assess psoriasis severity. When used in conjunction with narrow-band ultraviolet B (NB-UVB), a common type of phototherapy used to treat psoriasis, vitamin D consistently lowered IL-6, IL-17, and IL-23. These are pro-inflammatory cytokines that drive chronic inflammation in autoimmune conditions like psoriasis. Curcumin supplementation was associated with reduced levels of IL-22, another cytokine implicated in chronic inflammatory diseases like psoriasis. *Front Nutr. 2025 Dec 11:12:1718828.